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4 Prescribing Questions Before Elagolix for Endometriosis

Review the duration limit, bone health, pregnancy prevention and mood warnings before starting Orilissa.

Woman reviewing unmarked medicine packaging at a kitchen counter.
In this article
  1. Four prescribing questions
  2. Keep the contact plan accessible

When pain keeps rearranging your plans, a new prescription can bring hope and another set of questions. Before starting elagolix, ask the prescriber to put the treatment limits and safety plan beside the intended benefit. Keep that explanation with your medication instructions.

Four prescribing questions

  1. What is my treatment deadline? The permitted duration depends on the dose and liver health. Ask for your maximum duration and review date in writing.1

  2. Does my bone history change the plan? Known osteoporosis is a contraindication. The label advises considering bone-density assessment for people with a low-trauma fracture history or other bone-loss risks.1

  3. What contraception should I use? The label requires effective nonhormonal contraception during treatment and for 28 days afterward. Hormonal contraceptives can interact. Reduced bleeding may make pregnancy harder to recognize.1

  4. Which mood changes need attention? New or worsening depression, anxiety or other mood changes need prompt medical attention. Suicidal thoughts or behavior require immediate help.1

Keep the contact plan accessible

If you think you are pregnant, stop Orilissa and contact the prescriber immediately.1 Ask which number to use for medication concerns and what to do outside office hours.

Bring your medicine and supplement list to the prescribing visit. Ask the team to review the full Medication Guide with you, including the instructions that apply to your circumstances.

Period, Handled includes a Period Scorecard and visit script. Use them to organize the concerns and questions you want to discuss at a review. See the book.

This article is for general educational purposes only and is not medical advice. It isn't a substitute for diagnosis or treatment from a qualified healthcare professional who knows your health history. Please don't ignore professional advice or delay getting care because of something you read here. If you think you may be having a medical emergency, call 911 or your local emergency number right away. Girl Playbook does not endorse any specific product, test, or provider.

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Girl Playbook sells this book. It provides education and worksheets, not individualized medical care.

Sources

The research behind this article, in the order it’s cited. How we source our articles.

  1. AbbVie / DailyMed, National Library of Medicine, 2025ORILISSA (elagolix): prescribing information and Medication Guide (opens in a new tab)abcdef

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