4 Checks on Trifarotene and Acne Scars

Aklief, the trifarotene 0.005% cream, is approved in the US for acne in people 9 and older. Its indication does not include scar removal. A study of acne with sunken scars provides a narrower answer.¹

Check who was studied

The double-blind trial included 121 people ages 17–34, 73% women, with moderate-to-severe facial acne and existing atrophic, or sunken, scars. For 24 weeks, each person used trifarotene 50 micrograms/g daily on one randomly assigned facial half and inactive cream on the other.²

Read the scar numbers carefully

At 24 weeks, the abstract reports average scar-count reductions of 5.9 versus 2.7; the full text reports 6.2 versus 2.8, favoring trifarotene. The publication does not explain that discrepancy.²

Only three participants had Fitzpatrick type VI skin. This design cannot establish how well treatment removes longstanding scars after acne has stopped. Galderma funded the trial; three authors were employees.²

Name the mark you want treated

A flat patch of color after a breakout is usually not a scar. Sunken scars change the skin’s texture; raised scars need a different assessment. Show the dermatologist the particular marks you want assessed rather than asking for one treatment for every mark.³

The American Academy of Dermatology⁴ says scar treatment usually starts after acne is controlled. For mild scarring, a topical retinoid can make scars less noticeable. Scar type, skin tone and current breakouts affect the plan. Our acne-scar consultation questions can help organize that discussion.⁴

Get an irritation plan

Trifarotene can cause redness, scaling, dryness and stinging. Its label recommends moisturizer from the start and, when needed, reduced application frequency or a temporary pause. Avoid treated-skin waxing and application to eczema, cuts or sunburn. Use sunscreen and protective clothing when exposure cannot be avoided. Discuss pregnancy plans and other acne products with the prescriber.¹

Ask which symptoms should prompt a call and when the clinician wants to review progress. Keep dated photographs so you can compare the same areas.

Skin, Head to Toe describes a Skin Log with photographs every two to four weeks, treatment start dates and irritation notes. Use consistent lighting and front-and-side views. See the book.