PeriodsEvidence check
Best Painkillers for Period Cramps: What 80 Trials Found
Anti-inflammatory painkillers like ibuprofen and naproxen have the strongest trial record for period cramps. Across 80 trials, about half of women got moderate or excellent relief on them, against 18% on placebo, and no single brand stood out. The combined pill also eased cramps, at the cost of more irregular bleeding. Here is what the reviews found and when cramps need a closer look.











